{"Abbreviation":["2,4,5-T"],"Adverse Effects":"Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.","Aliases":["2,4,5-T","Trioxon","Fence rider","BCF-Bushkiller","Tippontormona","Arbokan","Forron","Phortox","Reddon","Reddox","Spontox","Verton 2T","Brush Killer","Line rider","Fruitone A","Envert-T","Decamine 4T","Brush RHAP","Brushtox","Crossbow","Forst U 46","Tippon","Inverton 245","VEON","Acetic acid, (2,4,5-trichlorophenoxy)-"],"Biological Half-Life":"/IN MALE SPRAGUE-DAWLEY RATS/ ALTHOUGH THE PLASMA HALF-LIFE OF ACUTE DOSES LESS THAN 50 MG/KG IS APPROX 4.2 HR, CHRONIC ADMIN OF SINGLE DAILY DOSES OF 20 MG/KG 2,4,5-T RESULTS IN APPARENT ACCUMULATION.","Boiling Point":"Decomposes (NTP, 1992)","CAS":"93-76-5","ChEBI":"CHEBI:27903","ChEMBL":"CHEMBL194458","ChemicalClasses":["carboxylic acid"],"Chirality":"achiral","Classes":["Herbicide"],"Color/Form":"WHITE SOLID","Decomposition":"Toxic gases and vapors /which include/: hydrogen chloride and carbon monoxide.","Density":"1.803 at 68 °F (USCG, 1999) - Denser than water; will sink g/cm\u003csup\u003e3\u003c/sup\u003e","EINECS":"202-273-3","Ecotoxicity Values":"LC50 Salmo gairdneri (rainbow trout) 350 mg/l/96 hr /Conditions of bioassay not given/","Esters":[],"European Community (EC) Number":"202-273-3","Formating":[],"HMDB ID":"HMDB0245475","Health Effects":"Exposure to large amounts of CDDs causes chloracne, a severe skin disease with acne-like lesions that occur mainly on the face and upper body. CDDs may also cause liver damage and induce long-term alterations in glucose metabolism and subtle changes in hormonal levels. In addition, studies have shown that CDDs may disrupt the endocrine system and weaken the immune system, as well as cause reproductive damage and birth defects, central and peripheral nervous system pathology, thyroid disorders, endometriosis, and diabetes. 2,3,7,8-Tetrachlorodibenzo-p-dioxin is also a known human carcinogen. (L177, L178)","HeavyAtomCount":14,"IUPACName":"2-(2,4,5-trichlorophenoxy)acetic acid","InChI":"InChI=1S/C8H5Cl3O3/c9-4-1-6(11)7(2-5(4)10)14-3-8(12)13/h1-2H,3H2,(H,12,13)","InChIKey":"SMYMJHWAQXWPDB-UHFFFAOYSA-N","Interactions":"... The effects of 2,4,5-T were enhanced when 5,5,5-tributyl phosphotrithiolate was applied to four woody species of plants.","LD50":[{"dosages":[{"amount":"300 mg/kg","route":"oral"},{"amount":"1535 mg/kg","route":"skin"}],"organism":"Rat"},{"dosages":[{"amount":"242 mg/kg","route":"oral"}],"organism":"Mouse"},{"dosages":[{"amount":"381 mg/kg","route":"oral"}],"organism":"Guinea pig"},{"dosages":[{"amount":"310 mg/kg","route":"oral"}],"organism":"Chicken"},{"dosages":[{"amount":"500 mg/kg","route":"oral"}],"organism":"Mammal (species unspecified)"},{"dosages":[{"amount":"425 mg/kg","route":"oral"}],"organism":"Hamster"},{"dosages":[{"amount":"100 mg/kg","route":"oral"}],"organism":"Dog"}],"MeSH Pharmacological Classification":"Pesticides used to destroy unwanted vegetation, especially various types of weeds, grasses (POACEAE), and woody plants. Some plants develop HERBICIDE RESISTANCE.","Melting Point":"316 °","MolecularFormula":"C\u003csub\u003e8\u003c/sub\u003eH\u003csub\u003e5\u003c/sub\u003eCl\u003csub\u003e3\u003c/sub\u003eO\u003csub\u003e3\u003c/sub\u003e","MolecularWeight":"255.5 g/mol","Non-Human Toxicity Values":"LD50 Mouse oral 389 mg/kg","Odor":"Odorless","Physical Description":"2,4,5-trichlorophenoxyacetic acid is a light tan solid (melting point 153 °C). Insoluble in water. Contact may irritate the skin.","PubChemId":1480,"RefCount":3,"RefCur":"","References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/2,4,5-Trichlorophenoxyacetic_acid","Name":"2,4,5-Trichlorophenoxyacetic acid","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q209188","Name":"2,4,5-Trichlorophenoxyacetic acid","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/1480","Name":"2,4,5-Trichlorophenoxyacetic acid","Sub":false}]},{"Name":"ChEMBL","Urls":[{"Link":"https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL194458","Name":"2,4,5-Trichlorophenoxyacetic acid","Sub":false}]},{"Name":"ChEBI","Urls":[{"Link":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:27903","Name":"2,4,5-Trichlorophenoxyacetic acid","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=93-76-5","Name":"2,4,5-Trichlorophenoxyacetic acid","Sub":false}]},{"Name":"HMDB","Urls":[{"Link":"https://hmdb.ca/metabolites/HMDB0245475","Name":"2,4,5-Trichlorophenoxyacetic acid","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/C07100","Name":"2,4,5-Trichlorophenoxyacetic acid","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/9Q963S4YMX","Name":"2,4,5-Trichlorophenoxyacetic acid","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021388","Name":"2,4,5-Trichlorophenoxyacetic acid","Sub":false}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 1480, 2,4,5-Trichlorophenoxyacetic acid. Accessed September 13, 2025. \u003ca href=https://pubchem.ncbi.nlm.nih.gov/compound/1480\u003ehttps://pubchem.ncbi.nlm.nih.gov/compound/1480\u003c/a\u003e","U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. 2,4,5-Trichlorophenoxyacetic acid. UNII: 9Q963S4YMX. Global Substance Registration System. Accessed September 13, 2025. \u003ca href=https://gsrs.ncats.nih.gov/ginas/app/beta/substances/9Q963S4YMX\u003ehttps://gsrs.ncats.nih.gov/ginas/app/beta/substances/9Q963S4YMX\u003c/a\u003e"],"SMILES":"C1=C(C(=CC(=C1Cl)Cl)Cl)OCC(=O)O","SaltData":[],"Salts":[],"Solubility":"less than 0.1 mg/mL at 69.8 °F (NTP, 1992)","Stability/Shelf Life":"STABLE @ ITS MELTING-POINT","StereoisomerData":[],"Stereoisomers":[],"Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" style=\"display:block\" viewBox=\"0 0 90.126 89.988\"\u003e\u003crect width=\"100%\" height=\"100%\" fill=\"#fff\"/\u003e\u003cdesc\u003eGenerated by the Chemistry Development Kit (http://github.com/cdk)\u003c/desc\u003e\u003cg fill=\"#ff0d0d\" stroke=\"#000\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\".7\"\u003e\u003cpath fill=\"#fff\" stroke=\"none\" d=\"M0 0h91v90H0z\"/\u003e\u003cg class=\"mol\"\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m46.72 48.801-.005 15.249M49.158 50.209l-.004 12.433\"/\u003e\u003c/g\u003e\u003cpath d=\"m46.72 48.801 13.203-7.628\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m73.121 48.793-13.198-7.62M70.683 50.2l-10.759-6.211\"/\u003e\u003c/g\u003e\u003cpath d=\"m73.121 48.793-.004 15.248\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m59.913 71.67 13.204-7.629M59.913 68.854l10.766-6.22\"/\u003e\u003c/g\u003e\u003cpath d=\"m46.715 64.05 13.198 7.62M59.913 71.67l.002 11.3M73.117 64.041l10.252 5.92M59.923 41.173l-.002-11.322M46.72 48.801l-9.923-5.729M33.522 37.26V25.941M33.522 25.941l-13.198-7.62\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"M19.104 19.025V7.002M21.543 19.025V7.002\"/\u003e\u003cpath stroke=\"#ff0d0d\" d=\"M19.104 7.002v6.011M21.543 7.002v6.011\" class=\"hi\"/\u003e\u003c/g\u003e\u003cpath d=\"m20.324 18.321-9.92 5.727\" class=\"bond\"/\u003e\u003cpath fill=\"#1ff01f\" stroke=\"none\" d=\"M60.41 84.933q-.786 0-1.238.53-.453.524-.453 1.447 0 .91.417 1.446.423.53 1.268.53.321 0 .607-.054.292-.059.566-.142v.535q-.274.102-.566.149-.291.054-.696.054-.744 0-1.25-.31-.5-.309-.751-.875-.25-.571-.25-1.339 0-.744.268-1.31.274-.566.804-.881.53-.322 1.28-.322.78 0 1.351.286l-.244.524q-.226-.101-.506-.184-.274-.084-.607-.084m2.757 4.423h-.602v-5.215h.602zM86.809 69.685q-.786 0-1.238.53-.453.523-.453 1.446 0 .911.417 1.447.423.53 1.268.53.321 0 .607-.054.292-.06.566-.143v.536q-.274.101-.566.149-.292.053-.696.053-.745 0-1.251-.309-.5-.31-.75-.875-.25-.572-.25-1.34 0-.744.268-1.309.274-.566.804-.882.53-.321 1.28-.321.78 0 1.351.286l-.244.524q-.226-.102-.506-.185-.274-.083-.607-.083m2.757 4.423h-.602v-5.215h.602zM60.415 23.956q-.786 0-1.238.53-.453.524-.453 1.447 0 .911.417 1.446.423.53 1.268.53.321 0 .607-.053.292-.06.566-.143v.535q-.274.102-.566.149-.292.054-.696.054-.745 0-1.251-.31-.5-.309-.75-.875-.25-.571-.25-1.339 0-.744.268-1.31.274-.566.804-.881.53-.321 1.28-.321.78 0 1.351.285l-.244.524q-.226-.101-.506-.184-.274-.084-.607-.084m2.757 4.423h-.602v-5.215h.602z\" class=\"atom\"/\u003e\u003cpath stroke=\"none\" d=\"M35.781 41.178q0 .756-.256 1.328-.256.565-.756.881-.5.315-1.244.315-.756 0-1.262-.315-.506-.316-.756-.887-.244-.572-.244-1.334 0-.75.244-1.309.25-.566.756-.881t1.274-.316q.732 0 1.232.316.5.309.756.875.256.565.256 1.327m-3.864 0q0 .923.387 1.459.393.53 1.221.53.839 0 1.22-.53.387-.536.387-1.459 0-.929-.387-1.452-.381-.524-1.208-.524-.834 0-1.227.524-.393.523-.393 1.452M22.583 3.078q0 .756-.256 1.328-.256.565-.756.881-.5.315-1.244.315-.756 0-1.262-.315-.506-.316-.757-.887-.244-.572-.244-1.334 0-.75.244-1.309.251-.566.757-.881T20.339.56q.732 0 1.232.316.5.309.756.875.256.565.256 1.327m-3.864 0q0 .923.387 1.459.393.53 1.221.53.839 0 1.22-.53.387-.536.387-1.459 0-.929-.387-1.452-.381-.524-1.208-.524-.834 0-1.227.524-.393.523-.393 1.452\" class=\"atom\"/\u003e\u003cg stroke=\"none\" class=\"atom\"\u003e\u003cpath d=\"M9.385 25.938q0 .756-.256 1.328-.256.565-.756.881-.5.315-1.245.315-.756 0-1.262-.315-.506-.316-.756-.887-.244-.572-.244-1.334 0-.75.244-1.309.25-.566.756-.881t1.274-.316q.733 0 1.233.316.5.309.756.875.256.565.256 1.327m-3.864 0q0 .923.387 1.459.393.53 1.22.53.84 0 1.221-.53.387-.536.387-1.459 0-.929-.387-1.452-.381-.524-1.209-.524-.833 0-1.226.524-.393.523-.393 1.452M4.305 28.391h-.62v-2.286H1.173v2.286H.56v-4.9h.613v2.072h2.512v-2.072h.62z\"/\u003e\u003c/g\u003e\u003cpath stroke=\"#1ff01f\" d=\"m59.915 82.97-.001-5.65M83.369 69.961l-5.126-2.96M59.921 29.851l.001 5.661\" class=\"hi\"/\u003e\u003cpath stroke=\"#ff0d0d\" d=\"m36.797 43.072 4.961 2.865M33.522 37.26V31.6M10.404 24.048l4.96-2.864M10.404 24.048l4.96-2.864\" class=\"hi\"/\u003e\u003c/g\u003e\u003c/g\u003e\u003c/svg\u003e","Subjective Effects":null,"Title":"2,4,5-Trichlorophenoxyacetic acid","Treatment":"Treatment may include washing any areas of contact, GI decontamination if swallowed, administering an IV and forced alkaline diuresis. (L346)","UNII":"9Q963S4YMX","Wikidata":"Q209188","Wikipedia":"2,4,5-Trichlorophenoxyacetic_acid","XLogP":3.3}